Stop worrying about the wrong things
Last week when Mark told me what some of the hot topics were at Windy City Rails, I commented that most people worry about scaling way too soon. For our own work at Stratepedia, I always say a scaling problem would be a good one to have. DHH says it more eloquently than I, in Signal vs. Noise.
http://37signals.com/svn/posts/2581-worrying-about-the-wrong-things